A Quiescent Bcl11b High Stem Cell Population Is Required for Maintenance of the Mammary Gland

详细信息    查看全文

• 作者：Shang Cai¹ ; Tomer Kalisky² ; ⁷ ; Debashis Sahoo¹ ; ³ ; Piero Dalerba¹ ; ⁴ ; ⁵ ; Weiguo Feng¹ ; ⁶ ; Yuan Lin¹ ; ⁶ ; Dalong Qian¹ ; Angela Kong¹ ; Jeffrey Yu¹ ; Flora Wang¹ ; Elizabeth Y. Chen¹ ; Ferenc A. Scheeren¹ ; ⁸ ; Angera H. Kuo¹ ; Shaheen S. Sikandar¹ ; Shigeo Hisamori¹ ; ⁹ ; Linda J. van Weele¹ ; Diane Heiser¹ ; Sopheak Sim¹ ; Jessica Lam¹ ; Stephen Quake² ; Michael F. Clarke¹ ; ¹⁰ ; ^{mfclarke@stanford.edu}
• 关键词：quiescence ; stem cell exhaustion
• 刊名：Cell Stem Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：20
• 期：2
• 页码：247-260.e5
• 全文大小：3615 K
• 卷排序：20

文摘

A subset of mammary basal epithelial cells express high levels of Bcl11b Loss of Bcl11b impairs mammary gland development and regenerative capacity Bcl11bhigh cells are quiescent but have potent regenerative activity in transplants