Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection

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Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection

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作者：Marcela Montes de Oca¹ ; ² ; Rajiv Kumar¹ ; ³ ; Fabian de Labastida Rivera¹ ; Fiona H. Amante¹ ; Meru Sheel¹ ; ¹⁰ ; Rebecca J. Faleiro¹ ; ⁴ ; Patrick T. Bunn¹ ; ⁵ ; Shannon E. Best¹ ; Lynette Beattie¹ ; Susanna S. Ng¹ ; ⁶ ; Chelsea L. Edwards¹ ; ² ; Glen M. Boyle¹ ; Ric N. Price⁷ ; ⁸ ; ⁹ ; Nicholas M. Anstey⁷ ; ⁸ ; Jessica R. Loughland⁷ ; ⁸ ; Julie Burel¹ ; Denise L. Doolan¹ ; ¹¹ ; Ashraful Haque¹ ; James S. McCarthy¹ ; ² ; ^{j.mccarthy@uq.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Christian R. Engwerda¹ ; ¹² ; ^{chrise@qimr.edu.au" class="auth_mail" title="E-mail the corresponding author}
关键词：malaria ; type I interferons ; CD4+ T cells ; immune regulation ; Tr1 cells ; Th1 cells
刊名：Cell Reports
出版年：2016
出版时间：4 October 2016
年：2016
卷：17
期：2
页码：399-412
全文大小：2559 K

文摘

•: Plasmodium falciparum-induced type I IFNs suppress Th1 cell development
•: Type I IFNs promote development of parasite-specific IL-10-producing Th1 (Tr1) cells
•: Chemoprophylaxis stimulates type I IFN-dependent, parasite-specific IL-10 production
•: Parasite-induced IL-10 suppresses inflammatory cytokine production

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