A XEN-like State Bridges Somatic Cells to Pluripotency during Chemical Reprogramming

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A XEN-like State Bridges Somatic Cells to Pluripotency during Chemical Reprogramming

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作者：Yang Zhao¹ ; ⁵ ; ^{yangzhao@pku.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Ting Zhao¹ ; ² ; ⁵ ; Jingyang Guan¹ ; ⁵ ; Xu Zhang¹ ; ⁵ ; Yao Fu¹ ; ⁵ ; Junqing Ye¹ ; ³ ; ⁵ ; Jialiang Zhu¹ ; Gaofan Meng¹ ; ³ ; Jian Ge¹ ; Susu Yang¹ ; Lin Cheng¹ ; Yaqin Du¹ ; Chaoran Zhao¹ ; Ting Wang¹ ; Linlin Su¹ ; Weifeng Yang⁴ ; Hongkui Deng¹ ; ³ ; ^{hongkui_deng@pku.edu.cn" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell
出版年：2015
出版时间：17 December 2015
年：2015
卷：163
期：7
页码：1678-1691
全文大小：4617 K

文摘

•: An extraembryonic endoderm (XEN)-like state mediates the process of CiPSC generation
•: XEN-like cells are transcriptionally and functionally similar to in vivo counterpart
•: XEN cells are primed to express Oct4 and establish pluripotency
•: CiPSC induction is greatly enhanced by manipulating precisely with small molecules

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