Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement

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Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement

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作者：Tingting Wang ; M.D.^a ; ^b ; ¹ ; Lei Zhang ; M.D. ; Ph.D.^c ; ¹ ; Jianqiang Hu ; M.D.^a ; ^b ; ¹ ; Yu Duan ; M.D.^a ; ¹ ; Mingming Zhang ; M.D.^a ; ^b ; Jie Lin ; M.D.^a ; ^b ; Wanrong Man ; M.D.^a ; ^b ; Xietian Pan ; M.D.^a ; ^b ; Zhenhua Jiang ; M.D.^a ; Guoyong Zhang ; M.D.^a ; Beilei Gao ; M.D.^a ; Haichang Wang ; M.D. ; Ph.D.^a ; ^b ; ^{wanghc@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Dongdong Sun ; M.D. ; Ph.D.^a ; ^b ; ^{wintersun3@gmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Atherosclerosis ; Autophagy ; Mammalian Ste20-like kinase 1 ; Mst1 ; Macrophages
刊名：Journal of Molecular and Cellular Cardiology
出版年：2016
出版时间：September 2016
年：2016
卷：98
期：Complete
页码：108-116
全文大小：1815 K

文摘

•: Mst1 is proposed as a new target for treating atherosclerosis.
•: The mechanism relies on stabilization of vulnerable plaque.
•: Macrophage autophagy and apoptosis should be modulated to inhibit atherosclerosis.

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