Single injection of a novel nerve growth factor coacervate improves structural and functional regeneration after sciatic nerve injury in adult rats

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• 作者：Rui Li^a ; ^b ; ¹ ; ^{791853868@qq.com} ; Jiang Wu^a ; ^b ; ¹ ; ^{woody870402@zju.edu.cn} ; Zhenkun Lin^a ; ¹ ; ^{zklin@wmu.edu.cn} ; Matthew R. Nangle^a ; ^c ; ¹ ; ^{m.nangle@uq.edu.au} ; Yi Li^b ; ^{liyi20060507@163.com} ; Pingtao Cai^b ; ^{1261206149@qq.com} ; Dan Liu^b ; ^{1328251262@qq.com} ; Libin Ye^b ; ^{190435904@qq.com} ; Zecong Xiao^b ; ^{xiaozecong.1314@qq.com} ; Chaochao He^b ; ^{928282661@qq.com} ; Jingjing Ye^b ; ^{jbb_2006@126.com} ; Hongyu Zhang^b ; ^{st_hyz@126.com} ; Yingzheng Zhao^b ; ^{lwhwz1@126.com} ; Jian Wang^d ; ^{lswangjw@sina.com} ; Xiaokun Li^b ; ^{xiaokunli@163.net} ; Yan He^a ; ^c ; ^{h.he@uq.edu.au} ; Qingsong Ye^a ; ^c ; ^{qingsongye@hotmail.com} ; Jian Xiao^a ; ^b ; ^{xfxj2000@126.com}
• 关键词：Peripheral nerve regeneration ; Controlled release ; Nerve growth factor ; Heparin ; Coacervate ; Sciatic nerve injury
• 刊名：Experimental Neurology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：288
• 期：Complete
• 页码：1-10
• 全文大小：2721 K
• 卷排序：288

文摘

Nerve growth factor plays an important role in survival, development, function and plasticity of many neurons Use of growth factors after injury is hampered by their short half-life and poor retention at the injury site Single injection of a novel slow-release nerve growth factor coacervate can improve structural and functional regeneration