C-Myc negatively controls the tumor suppressor PTEN by upregulating miR-26a in glioblastoma multiforme cells

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• 作者：Pin Guo ; Quanmin Nie ; Jin Lan ; Jianwei Ge ; Yongming Qiu ; Qing Mao
• 关键词：PTEN ; phosphatase and tensin homolog located on chromosome 10 ; GBM ; glioblastoma multiforme ; miRNA ; microRNA ; 3&prime ; -UTR ; 3&prime ; -untranslated region ; BCL ; B-cell lymphoma ; AML ; acute myeloid leukemia ; CCK-8 ; Cell Counting Kit-8
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：8 November, 2013
• 年：2013
• 卷：441
• 期：1
• 页码：186-190
• 全文大小：796 K

文摘

The c-Myc oncogene is amplified in many tumor types. It is an important regulator of cell proliferation and has been linked to altered miRNA expression, suggesting that c-Myc-regulated miRNAs might contribute to tumor progression. Although miR-26a has been reported to be upregulated in glioblastoma multiforme (GBM), the mechanism has not been established. We have shown that ectopic expression of miR-26a influenced cell proliferation by targeting PTEN, a tumor suppressor gene that is inactivated in many common malignancies, including GBM. Our findings suggest that c-Myc modulates genes associated with oncogenesis in GBM through deregulation of miRNAs via the c-Myc-miR-26a-PTEN signaling pathway. This may be of clinical relevance.