Docosahexaenoic acid signaling attenuates the proliferation and differentiation of bone marrow-derived osteoclast precursors and promotes apoptosis in mature osteoclasts

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• 作者：Hyun-Ju Kim^a ; ^b ; ^{biohjk@knu.ac.kr} ; Boram Ohk^a ; Hye Jin Yoon^a ; Woo Youl Kang^a ; Sook Jin Seong^a ; Shin-Yoon Kim^b ; Young-Ran Yoon^a ; ^{yry@knu.ac.kr}
• 关键词：BMM ; bone marrow macrophage ; DHA ; docosahexaenoic acid ; EPA ; eicosapentaenoic acid ; M-CSF ; macrophage colony-stimulating factor ; NFATc1 ; nuclear factor of activated T cells c1 ; RANKL ; receptor activator of NF-κB ligand ; TRAP ; tartrate-resistant acid phosphatase
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：29
• 期：Complete
• 页码：226-232
• 全文大小：803 K
• 卷排序：29

文摘

DHA inhibits osteoclast formation from mouse bone marrow-derived macrophages. DHA attenuates precursor proliferation by suppressing M-CSF-induced Akt activation and D-type cyclin expression. DHA inhibits osteoclastogenesis by blocking RANKL-induced activation of NF-κB and MAPKs. DHA accelerates osteoclast apoptosis by enhancing Bim expression.