Recombinant DNA vaccine of Hantavirus Gn and LAMP1 induced long-term immune protection in mice

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• 作者：Dong-Bo Jiang^a ; ¹ ; Li-Juan Sun^b ; ¹ ; Lin-Feng Cheng^c ; ¹ ; Jin-Peng Zhang^a ; ¹ ; Shao-Bo Xiao^a ; Yuan-Jie Sun^a ; Shu-Ya Yang^a ; Jing Wang^a ; Fang-Lin Zhang^c ; ^{flzhang@fmmu.edu.cn} ; Kun Yang^a ; ^{yangkunkun@fmmu.edu.cn}
• 关键词：DNA vaccine ; Hantavirus ; Glycoprotein N-terminal ; Lysosome-associated membrane protein ; Memory immune response
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：138
• 期：Complete
• 页码：32-39
• 全文大小：2124 K
• 卷排序：138

文摘

Hantavirus (HTV) DNA vaccine pVAX-LAMP/Gn established memory immune responses. Only pVAX-LAMP/Gn gained long-term seroconversion compared with inactivated vaccine. Enhanced CTL cytotoxicity and Th IFN-γ activity defined cellular memory immunity. Epitope-spreading phenomenon suggested cross-species T-cell hot-spot on Hantaan virus Gn. Safety of pVAX-LAMP/Gn was reconfirmed through behavioral and histological analysis.