Apocynin attenuates isoproterenol-induced myocardial injury and fibrogenesis

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Apocynin attenuates isoproterenol-induced myocardial injury and fibrogenesis

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作者：Li Liu^b ; ¹ ; Jingang Cui^a ; ^b ; ¹ ; Qinbo Yang^a ; ^b ; Chenglin Jia^b ; Minqi Xiong^b ; Bingbing Ning^b ; Xiaoye Du^a ; ^b ; Peiwei Wang^a ; ^b ; Xintong Yu^a ; ^b ; Li Li^a ; ^b ; Wenjian Wang^a ; ^b ; Yu Chen^a ; ^b ; ^{chenyu6639@gmail.com" class="auth_mail} ; Teng Zhang^a ; ^b ; ^{zhangteng501@hotmail.com" class="auth_mail}
关键词：Myocardial injury ; Fibrosis ; Reactive oxygen species ; Apocynin ; Gene expression
刊名：Biochemical and Biophysical Research Communications
出版年：20 June 2014
年：2014
卷：449
期：1
页码：55-61
全文大小：2004 K

文摘

•: Apocynin attenuated the development of ISO-induced myocardial injury and fibrosis in the mouse.
•: Apocynin suppressed NADPH oxidase-mediated ROS generation in ISO-challenged mouse heart.
•: Apocynin decreased the expression of genes implicated in inflammatory response.
•: Apocynin decreased the expression of genes implicated in fibrogenic response.

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