Erythropoietin Stimulates Tumor Growth via EphB4

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Erythropoietin Stimulates Tumor Growth via EphB4

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作者：Sunila Pradeep¹ ; ¹⁸ ; Jie Huang¹ ; ¹⁸ ; Edna M. Mora² ; ³ ; ⁴ ; ¹⁸ ; Alpa M. Nick¹ ; Min Soon Cho⁵ ; Sherry Y. Wu¹ ; Kyunghee Noh¹ ; Chad V. Pecot⁶ ; Rajesha Rupaimoole¹ ; Martin A. Stein⁷ ; Stephan Brock⁷ ; Yunfei Wen¹ ; Chiyi Xiong⁸ ; Kshipra Gharpure¹ ; Jean M. Hansen¹ ; Archana S. Nagaraja¹ ; Rebecca A. Previs¹ ; Pablo Vivas-Mejia² ; Hee Dong Han¹ ; ⁹ ; Wei Hu¹ ; Lingegowda S. Mangala¹ ; ⁹ ; Behrouz Zand¹ ; Loren J. Stagg¹⁰ ; John E. Ladbury¹⁰ ; Bulent Ozpolat¹¹ ; S. Neslihan Alpay¹¹ ; Masato Nishimura¹ ; Rebecca L. Stone¹ ; Koji Matsuo¹ ; Guillermo N. Armaiz-Peñ ; a¹ ; Heather J. Dalton¹ ; Christopher Danes¹ ; Blake Goodman¹ ; Cristian Rodriguez-Aguayo¹¹ ; Carola Kruger¹² ; Armin Schneider¹² ; Shyon Haghpeykar¹ ; Padmavathi Jaladurgam¹ ; Mien-Chie Hung¹³ ; ¹⁷ ; Robert L. Coleman¹ ; Jinsong Liu¹⁴ ; Chun Li¹⁰ ; Diana Urbauer¹⁵ ; Gabriel Lopez-Berestein⁹ ; ¹¹ ; David B. Jackson⁷ ; Anil K. Sood¹ ; ⁹ ; ¹⁶ ; ^{asood@mdanderson.org" class="auth_mail" title="E-mail the corresponding author}
刊名：Cancer Cell
出版年：2015
出版时间：9 November 2015
年：2015
卷：28
期：5
页码：610-622
全文大小：3918 K

文摘

•: EphB4 functions as a canonical Epo receptor
•: rhEpo-mediated EphB4 activation triggers downstream signaling via STAT3
•: rhEpo induces EphB4-mediated functional and biological effects
•: EphB4 expression negatively correlates with clinical outcome

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