Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells

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• 作者：Xiong-jun Wang¹ ; ² ; ⁸ ; Yunbo Qiao³ ; ⁴ ; ⁸ ; Minzhe M. Xiao¹ ; ⁸ ; Lingbo Wang³ ; Jun Chen³ ; ⁵ ; Wenjian Lv³ ; Li Xu⁶ ; Yan Li⁶ ; Yumei Wang¹ ; Ming-dian Tan¹ ; Chao Huang¹ ; Jinsong Li³ ; Ting C. Zhao⁷ ; Zhaoyuan Hou² ; ⁹ ; ^{houzy@sjtu.edu.cn} ; Naihe Jing³ ; ⁹ ; ^{njing@sibs.ac.cn} ; Y. Eugene Chin¹ ; ⁹ ; ^{yechin@sibs.ac.cn}
• 关键词：STAT3 ; embryonic stem cells ; self-renewal ; differentiation ; MAPK ; acetylation ; phosphorylation ; signaling ; LIF ; LIFR
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：24 January 2017
• 年：2017
• 卷：18
• 期：4
• 页码：933-946
• 全文大小：4620 K
• 卷排序：18

文摘

LIFR acetylation induced by LIF facilitates its homodimerization and gp130 recruitment Acetylated LIFR is responsible for STAT3 activation Phosphorylation at the LIFR C tail 4SPXS repeats suppresses LIF signaling LIFR acetylation and phosphorylation differentially regulate mESC pluripotency