Combinatorial Screening Identifies Novel Promiscuous Matrix Metalloproteinase Activities that Lead to Inhibition of the Therapeutic Target IL-13

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Combinatorial Screening Identifies Novel Promiscuous Matrix Metalloproteinase Activities that Lead to Inhibition of the Therapeutic Target IL-13

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作者：Carole Urbach¹ ; ^{urbachc@medimmune.com" class="auth_mail" title="E-mail the corresponding author} ; Nathaniel C. Gordon¹ ; ⁶ ; Ian Strickland² ; David Lowne¹ ; ⁷ ; Cathy Joberty-Candotti³ ; Richard May² ; Athula Herath⁴ ; DirkJan Hijnen⁵ ; Judith L. Thijs⁵ ; Carla A. Bruijnzeel-Koomen⁵ ; Ralph R. Minter¹ ; Florian Hollfelder⁶ ; Lutz Jermutus¹
刊名：Chemistry & Biology
出版年：2015
出版时间：19 November 2015
年：2015
卷：22
期：11
页码：1442-1452
全文大小：1326 K

文摘

•: Combinatorial screening identifies previously unknown protease activities
•: Several MMPs degrade and neutralize IL-13, a target in asthma
•: MMP-8 is a protease lead that could become a therapeutic molecule

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