Molecular mechanisms controlling synaptic recruitment of GluA4 subunit-containing AMPA-receptors critical for functional maturation of CA1 glutamatergic synapses

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Molecular mechanisms controlling synaptic recruitment of GluA4 subunit-containing AMPA-receptors critical for functional maturation of CA1 glutamatergic synapses

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作者：Natalia V. Luchkina^a ; ^b ; Sarah K. Coleman^b ; ² ; Johanna Huupponen^a ; ^b ; Chunlin Cai^b ; ¹ ; Anna Kivistö ; ^a ; Tomi Taira^a ; ^c ; Kari Keinä ; nen^b ; Sari E. Lauri^a ; ^b ; ^{sari.lauri@helsinki.fi" class="auth_mail" title="E-mail the corresponding author}
关键词：AMPA &ndash ; receptor ; GluA4 ; Silent synapse ; Development ; Synaptic targeting
刊名：Neuropharmacology
出版年：2017
出版时间：January 2017
年：2017
卷：112
期：part_PA
页码：46-56
全文大小：1944 K

文摘

•: PKA activation leads to synaptic unsilencing via insertion of GluA4.
•: This depends on a novel mechanism involving the extreme C-terminal end of GluA4.
•: Absence of GluA4 causes delayed postnatal maturation of AMPA transmission.

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