Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue

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• 作者：Carly T. Cederquist¹ ; Claudia Lentucci¹ ; Camila Martinez-Calejman³ ; Vanessa Hayashi¹ ; Joseph Orofino¹ ; David Guertin³ ; Susan K. Fried⁴ ; Mi-Jeong Lee² ; M. Dafne Cardamone¹ ; Valentina Perissi¹ ; ^{vperissi@bu.edu}
• 关键词：Adipose tissue ; Obesity ; Insulin ; AKT ; Ubiquitin ; GPS2
• 刊名：Molecular Metabolism
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：6
• 期：1
• 页码：125-137
• 全文大小：1836 K
• 卷排序：6

文摘

Ubc13-mediated ubiquitination of AKT is required for activation of the insulin signaling pathway. GPS2 regulates insulin signaling by inhibiting AKT ubiquitination and activation. Adipo-specific deletion of GPS2 results in increased adiposity and altered lipid flux in the adipocytes. GPS2-AKO mice have higher levels of circulating adiponectin and are insulin sensitive despite being obese.