MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A

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• 作者：Cui Chang^a ; Te Liu^b ; ^c ; ^{te.liu@yale.edu} ; Yongyi Huang^d ; Wenxing Qin^f ; Hongtu Yang^a ; ^{yht2113@126.com} ; Juan Chen^e ; ^{406526258@qq.com}
• 关键词：miRNAs ; microRNAs ; OCSCs ; ovarian cancer stem cells ; Dlk1 ; Delta-like homolog 1 ; Rtl1/Mart1 ; retrotransposon-like gene 1 ; Dio3 ; type 3 deiodinase ; ncRNAs ; non-coding RNAs ; Meg3 ; Maternally expressed gene 3 ; Gtl2 ; gene trap locus 2 ; snoRNA ; small nucleolar RNA ; Mirg ; microRNA-containing gene ; Rtl1as ; RTL1 antisense ; iPS ; induced pluripotent stem cells ; mESCs ; mouse embryo stem cells ; KRAS ; Kirsten rat sarcoma viral oncogene homolog ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazolium-bromid
• 刊名：Gene
• 出版年：2017
• 出版时间：20 March 2017
• 年：2017
• 卷：605
• 期：Complete
• 页码：99-107
• 全文大小：1491 K
• 卷排序：605

文摘

DLK1-DIO3 microRNA cluster has different expression between OCSCs and OCCs (CD44 −/CD133 −). Low miR-134-3p in OCSCs correlates with RAB27a overexpression. We confirmed RAB27a mRNA a novel target of miR-134-3p. Overexpression for miR-134-3p inhibits OCSCs in vitro. MiR-134-3p transfection decreases OCSCs xenograft tumor growth.