Glutathione maintenance mitigates age-related susceptibility to redox cycling agents

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Glutathione maintenance mitigates age-related susceptibility to redox cycling agents

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作者：Nicholas O. Thomas^a ; ^b ; Kate P. Shay^a ; Amanda R. Kelley^a ; ^b ; Judy A. Butler^a ; Tory M. Hagen^a ; ^b ; ^{tory.hagen@oregonstate.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：ARE ; Antioxidant Response Element ; BSO ; Buthionine-S ; R-Sulfoximine ; CPR ; Cytochrome P450 reductase ; DCPIP ; Dichlorophenolindophenol ; GPX4 ; Glutathione Peroxidase 4 ; LDHA ; Lactate dehydrogenase A ; LOO ; Lipid peroxide ; MDA ; Malonyldialdehyde ; NQO1 ; NAD(P)H ; quinone oxido-reductase 1 ; NQO2 ; NAD(P)H ; quinone oxido-reductase 2 ; Nrf2 ; Nuclear factor (erythroid-derived 2)-like 2 ; RIPA ; Radioimmunoprecipitation assay ; TRE ; TPA-Response Element
刊名：Redox Biology
出版年：2016
出版时间：December 2016
年：2016
卷：10
期：Complete
页码：45-52
全文大小：997 K

文摘

•: Menadione toxicity is nearly two-fold higher with age by LC₅₀ in F344 hepatocytes.
•: Glutathione (GSH) loss during menadione treatment is accelerated with age.
•: Age-related loss of GPX4 protein correlates with increased menadione-induced MDA.
•: NAC maintained GSH mitigates age-related susceptibility to redox cycling menadione.

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