Sarcomeric lesions and remodeling proximal to intercalated disks in overload-induced cardiac hypertrophy

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Sarcomeric lesions and remodeling proximal to intercalated disks in overload-induced cardiac hypertrophy

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作者：Sied Kebir^a ; ¹ ; ^{Sied.Kebir@ukb.uni-bonn.de" class="auth_mail" title="E-mail the corresponding author} ; Zacharias Orfanos^b ; ¹ ; ^{orfanos@uni-bonn.de" class="auth_mail" title="E-mail the corresponding author} ; Julia Schuld^b ; ¹ ; ^{julis@uni-bonn.de" class="auth_mail" title="E-mail the corresponding author} ; Markus Linhart^c ; ^{Markus.Linhart@ukb.uni-bonn.de" class="auth_mail" title="E-mail the corresponding author} ; Christian Lamberz^b ; ^{christian.lamberz@dzne.de" class="auth_mail" title="E-mail the corresponding author} ; Peter F.M. van der Ven^b ; ^{pvdven@uni-bonn.de" class="auth_mail" title="E-mail the corresponding author} ; Jan Schrickel^c ; ^{Jan.Schrickel@ukb.uni-bonn.de" class="auth_mail" title="E-mail the corresponding author} ; Gregor Kirfel^b ; ^{g.kirfel@uni-bonn.de" class="auth_mail" title="E-mail the corresponding author} ; Dieter O. Fü ; rst^b ; ² ; ^{dfuerst@uni-bonn.de" class="auth_mail" title="E-mail the corresponding author} ; Rainer Meyer^a ; ² ; ^{rainer.meyer@ukb.uni-bonn.de" class="auth_mail" title="E-mail the corresponding author}
关键词：Xin actin-binding repeat-containing proteins ; Xirp1 ; XIRP2 ; Cross-striated muscle cells ; Connexin43 ; Filamin C
刊名：Experimental Cell Research
出版年：2016
出版时间：15 October 2016
年：2016
卷：348
期：1
页码：95-105
全文大小：787 K

文摘

•: TAC induced remodeling in areas adjacent to intercalated disks.
•: Hypertrophic hearts show sarcomeric lesions like post-exercise skeletal muscles.
•: Filamin C and XIRP2 are markers of sarcomeric remodeling in the heart.
•: Xirp1-inactivated hearts only display a very mild phenotype.

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