Regular treadmill exercise inhibits mitochondrial accumulation of cholesterol and oxysterols during myocardial ischemia-reperfusion in wild-type and ob/ob mice

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• 作者：Julien Musman^a ; ^b ; Sandrine Pons^a ; ^b ; Caroline Barau^a ; ^b ; Claudio Caccia^c ; Valerio Leoni^c ; ^d ; Alain Berdeaux^a ; ^b ; Bijan Ghaleh^a ; ^b ; Didier Morin^a ; ^b ; ^{didier.morin@inserm.fr}
• 关键词：Ex ; exercised ; I/R ; ischemia-reperfusion ; mPTP ; mitochondrial permeability transition pore ; ob/ob mice ; leptin deficient mice ; ROS ; reactive oxygen species ; Sed ; sedentary ; WT ; wild-type
• 刊名：Free Radical Biology and Medicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：101
• 期：Complete
• 页码：317-324
• 全文大小：883 K
• 卷排序：101

文摘

Cardiac I/R increases mitochondrial cholesterol in wild-type and obese mice. The accumulation of mitochondrial cholesterol generates deleterious oxysterols. Physical exercise restores cardiac antioxidant capacity and oxidative phosphorylation. Physical exercise limits cholesterol and oxysterol accumulation induced by I/R. The reduction in sterol accumulation contributes to the protective effect of exercise.