Deficiency of dietary niacin impaired intestinal mucosal immune function via regulating intestinal NF-κB, Nrf2 and MLCK signaling pathways in young grass carp (Ctenopharyngodon idella)

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Deficiency of dietary niacin impaired intestinal mucosal immune function via regulating intestinal NF-κB, Nrf2 and MLCK signaling pathways in young grass carp (Ctenopharyngodon idella)

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作者：Lin Feng^a ; ^b ; ^c ; ¹ ; Shun-Quan Li^a ; ¹ ; Wei-Dan Jiang^a ; ^b ; ^c ; Yang Liu^a ; ^b ; ^c ; Jun Jiang^a ; ^b ; ^c ; Pei Wu^a ; ^b ; ^c ; Juan Zhao^a ; ^b ; ^c ; Sheng-Yao Kuang^d ; Ling Tang^d ; Wu-Neng Tang^d ; Yong-An Zhang^e ; Xiao-Qiu Zhou^a ; ^b ; ^c ; ^{xqzhouqq@tom.com" class="auth_mail" title="E-mail the corresponding author} ; ^{zhouxq@sicau.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Niacin ; Grass carp ; Mucosal immune ; Antioxidant capability ; Tight junction protein ; mRNA level ; Intestine
刊名：Fish & Shellfish Immunology
出版年：2016
出版时间：February 2016
年：2016
卷：49
期：Complete
页码：177-193
全文大小：3353 K

文摘

•: Niacin deficiency decreased fish intestinal immune and barrier function.
•: Niacin deficiency impaired intestinal TJ barrier function.
•: Niacin deficiency caused intestinal oxidative damage and decreased antioxidant capacity.
•: Niacin changed mRNA abundance of signaling molecules in NF-κB, MLCK and Nrf2 signaling pathways.