PPARγ activation ameliorates postoperative cognitive decline probably through suppressing hippocampal neuroinflammation in aged mice

详细信息    查看全文

• 作者：Zhijie Zhang^a ; ¹ ; Hongmei Yuan^b ; ¹ ; Huatang Zhao^c ; Bin Qi^a ; Fayin Li^a ; Lijun An^a ; ^{lijunan2000@126.com}
• 关键词：Postoperative cognitive decline ; PPARγ ; Aged ; Neuroinflammation
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：Complete
• 页码：53-61
• 全文大小：2201 K
• 卷排序：43

文摘

Neuroinflammation plays a key role in postoperative cognitive decline (POCD). PPARγ is involved in neuroinflammation and cognitive decline after surgery. Pioglitazone ameliorated the hippocampal inflammatory changes and POCD.