Kalirin is required for BDNF-TrkB stimulated neurite outgrowth and branching

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Kalirin is required for BDNF-TrkB stimulated neurite outgrowth and branching

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作者：Yan Yan^a ; Betty A. Eipper^a ; ^b ; Richard E. Mains^a ; ^{mains@uchc.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Rho GEF ; Kalrn knockout ; TrkB kinase ; TrkB phosphorylation ; ERK ; Akt ; CREB
刊名：Neuropharmacology
出版年：2016
出版时间：August 2016
年：2016
卷：107
期：Complete
页码：227-238
全文大小：2265 K

文摘

•: Kalirin is required for BDNF-stimulated dendritic outgrowth and branching.
•: BDNF/TrkB activation of Rac1 in neurons is largely mediated by Kalirin.
•: The Tiam1 fragment PHn-CC-EX blocks Tiam1 and Kalirin Rac1 activation.
•: Kalirin isoforms lacking the second GEF domain can rescue BDNF responsiveness.
•: Kalirin affects the time course of BDNF/TrkB pathway activation in neurons.

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