The kallikrein-related peptidase family: Dysregulation and functions during cancer progression

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The kallikrein-related peptidase family: Dysregulation and functions during cancer progression

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作者：T. Kryza^a ; ^b ; M.L. Silva^b ; D. Loessner^b ; N. Heuz&eacute ; -Vourc'h^c ; ^d ; ^e ; J.A. Clements^a ; ^b ; ^{j.clements@qut.edu.au" class="auth_mail" title="E-mail the corresponding author}
关键词：Kallikrein-related peptidase ; KLK ; Cancer ; Function ; Protease ; Carcinogenesis
刊名：Biochimie
出版年：2016
出版时间：March 2016
年：2016
卷：122
期：Complete
页码：283-299
全文大小：2003 K

文摘

•: Kallikrein-related peptidases are a family of 15 serine peptidases (KLK1-15).
•: They are dysregulated during cancer-progression and are useful biomarkers.
•: They regulate cancer cell growth, migration, invasion and chemo-resistance.
•: They modulate interactions between cell populations in the tumour microenvironment.
•: They are potent targets for drug development to counter-act cancer progression.

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