We characterized the role of the posterior cingulate cortex (pCC) in tasks requiring automatic and controlled semantic memory processing

Connectivity of posterior cingulate cortex (pCC) with dorsolateral prefrontal cortex (PFC) increased when performing demanding semantic tasks

Stronger functional coupling of pCC with dorsolateral PFC at rest predicted more efficient semantic task performance

Despite deactivating during demanding tasks, the pCC increases communication with prefrontal regions, suggesting a role in controlled cognition