IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain

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IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain

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作者：Prabesh Bhattarai¹ ; ² ; Alvin Kuriakose Thomas³ ; Mehmet Ilyas Cosacak¹ ; ² ; Christos Papadimitriou¹ ; ² ; Violeta Mashkaryan¹ ; ² ; Cynthia Froc⁴ ; Susanne Reinhardt² ; ⁵ ; Thomas Kurth² ; ⁵ ; Andreas Dahl² ; ⁵ ; Yixin Zhang³ ; Caghan Kizil¹ ; ² ; ⁶ ; ^{caghan.kizil@dzne.de" class="auth_mail" title="E-mail the corresponding author}
关键词：zebrafish ; neurodegeneration ; Amyloid-β42 ; interlukin-4 ; STAT6 ; neural stem cell ; regeneration ; Alzheimer&rsquo ; s disease ; inflammation ; neuro-immune crosstalk
刊名：Cell Reports
出版年：2016
出版时间：18 October 2016
年：2016
卷：17
期：4
页码：941-948
全文大小：4841 K

文摘

•: Amyloid-β42 (Aβ42) forms aggregates in neurons of adult zebrafish brain
•: Aβ42 causes apoptosis, inflammation, synaptic loss, and memory deficits in zebrafish
•: Aβ42 leads to interleukin-4 (IL4) upregulation in neurons and microglia
•: IL4/STAT6 signaling induces neural stem cell proliferation

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