Application of meso-hydrobenzoin-derived chiral auxiliaries for the stereoselective synthesis of highly substituted pyrrolidines by 1,3-dipolar cycloaddition of azomethine ylides

详细信息    查看全文

• 作者：Katharina Bica ; Peter Gaertner
• 刊名：Tetrahedron: Asymmetry
• 出版年：2010
• 出版时间：8 April 2010
• 年：2010
• 卷：21
• 期：6
• 页码：641-646
• 全文大小：612 K

文摘

The metal-catalyzed stereoselective 1,3-dipolar cycloaddition of azomethine ylides and acrylates using recyclable meso-hydrobenzoin-derived chiral auxiliaries is described. Cleavage of the auxiliary leads to highly substituted pyrrolidines in up to 87 % enantiomeric excess.