Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner

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Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner

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作者：Sung-Hak Kim¹ ; Ravesanker Ezhilarasan³ ; Emma Phillips⁴ ; Daniel Gallego-Perez⁵ ; ⁶ ; ⁷ ; ⁸ ; Amanda Sparks⁹ ; David Taylor⁹ ; Katherine Ladner¹⁰ ; Takuya Furuta¹¹ ; Hemragul Sabit¹¹ ; Rishi Chhipa¹² ; Ju Hwan Cho¹³ ; Ahmed Mohyeldin⁹ ; Samuel Beck¹⁴ ; Kazuhiko Kurozumi¹⁵ ; Toshihiko Kuroiwa¹⁶ ; Ryoichi Iwata¹⁷ ; Akio Asai¹⁷ ; Jonghwan Kim¹⁴ ; Erik P. Sulman³ ; Shi-Yuan Cheng¹⁸ ; L. James Lee⁷ ; ⁸ ; ¹⁹ ; Mitsutoshi Nakada¹¹ ; Denis Guttridge¹⁰ ; Biplab DasGupta¹² ; Violaine Goidts⁴ ; Krishna P. Bhat²⁰ ; Ichiro Nakano¹ ; ² ; ^{inakano@uabmc.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：glioblastoma ; cancer stem cell ; epithelial-to-mesenchymal transition ; proneural-mesenchymal transition
刊名：Cancer Cell
出版年：2016
出版时间：8 February 2016
年：2016
卷：29
期：2
页码：201-213
全文大小：4910 K

文摘

•: Silencing MLK4 attenuates mesenchymal identity in glioma stem cells
•: MLK4 activates NF-κB signaling by direct phosphorylation of IKKα
•: MLK4 promotes radioresistance in GBM
•: MLK4 expression negatively correlates with patient survival of MES but not PN GBM

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