Diet-induced obesity prolongs neuroinflammation and recruits CCR2<sup>+</sup> monocytes to the brain following herpes simplex virus (HSV)-1 latency in mice

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Diet-induced obesity prolongs neuroinflammation and recruits CCR2⁺ monocytes to the brain following herpes simplex virus (HSV)-1 latency in mice

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作者：Katherine A. White^a ; Scott R. Hutton^b ; Jill M. Weimer^a ; ¹ ; Patricia A. Sheridan^c ; ¹ ; ^{patti@email.unc.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：HSV-1 ; Obesity ; Neuroinflammation ; Anxiety ; Microglia and macrophage
刊名：Brain, Behavior, and Immunity
出版年：2016
出版时间：October 2016
年：2016
卷：57
期：Complete
页码：68-78
全文大小：1775 K

文摘

•: Neuroinflammation induced by obesity following HSV-1 infection is investigated.
•: Obesity promotes microglial inflammation following HSV-1 latency.
•: Obesity following HSV-1 latency results in recruitment of CCR2⁺ monocytes to the brain.
•: Obesity and latent HSV result in increased anxiety-like behavior.

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