Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor

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• 作者：Chris A. Brosey¹ ; ⁵ ; ^{cabrosey@mdanderson.org} ; Chris Ho¹ ; Winnie Z. Long¹ ; Sukrit Singh¹ ; Kathryn Burnett² ; Greg L. Hura² ; ³ ; Jay C. Nix⁴ ; Gregory R. Bowman¹ ; Tom Ellenberger¹ ; John A. Tainer² ; ⁵ ; ⁶ ; ^{jtainer@mdanderson.org}
• 关键词：apoptosis-inducing factor ; charge-transfer complex ; flavoswitch ; parthanatos ; mitochondrial homeostasis ; allostery ; SAXS ; X-ray crystallography ; molecular dynamics
• 刊名：Structure
• 出版年：2016
• 出版时间：6 December 2016
• 年：2016
• 卷：24
• 期：12
• 页码：2067-2079
• 全文大小：5050 K
• 卷排序：24

文摘

Disruption of AIF's C loop causes dimerization in the absence of NADH ligand Active-site residue H454 is coupled to AIF's dimerization surface AIF dimerization is regulated by a hydrophobic border at the dimer interface The Cβ-clasp is a focal point for C-loop remodeling during CTC formation