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class=""h4"">Purpose
To evaluate
capsular bag opa
cifi
cation with a new disk-shaped single-pie
ce hydrophili
c a
cryli
c intrao
cular lens (IOL) suspended between 2 hapti
c rings
conne
cted by a pillar of the hapti
c material and with a
commer
cially available single-pie
ce hydrophobi
c a
cryli
c IOL in rabbits.
class=""h4"">Setting
John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
class=""h4"">Design
Experimental study.
class=""h4"">Methods
The study IOL was implanted in the right eyes of 5 New Zealand rabbits and the control IOL in the left eyes. Slitlamp examination was performed at weeks 1 through 5. After the rabbits were humanely killed, the globes were enucleated and examined by ultrasound. Capsular bag opacification scoring from the posterior aspect (Miyake-Apple view) was then performed, followed by histopathology.
class=""h4"">Results
Trace honeycomb posterior capsule opacification (PCO) was noted in some study eyes. All control eyes developed moderate to marked PCO, which was more pronounced at the level of the optic¨Chaptic junction. The mean PCO score was 0.4 ¡À 0.22 (SD) in the study group and 3.4 ¡À 0.54 in the control group (P=.000179, paired t test). Minimal proliferative cortical material was confined to the space between the anterior and posterior rings of the study IOL haptics. Anterior capsule opacification was absent in study eyes and mild in control eyes. There was no contact between the anterior capsule and the anterior surface of study IOLs.
class=""h4"">Conclusion
The peripheral rings of the study IOL, by expanding the capsular bag and preventing IOL surface contact with the anterior capsule, appear to prevent opacification of the capsular bag.
class=""h4"">Financial Disclosure
No author has a financial or proprietary interest in any material or method mentioned.