文摘
Twenty-one hidradenomas from 20 patients (13 female, 7 male) ranging in age from 18 to 87 years (mean, 57.75 years; median, 60 years) were studied for m>CRTC1-MAML2m> and m>CRTC3-MAML2m> fusions to find out whether there is a correlation between the particular cell type (polyhedral eosinophilic, clear, mucinous, epidermoid, and oncocytic) and presence the above alterations. m>CRTC1-MAML2m> fusions were detected in 10 of the 21 neoplasms (47.6%). Fluorescence in situ hybridization for MAML2 break apart was analyzable in 13 specimens and in all these specimens was positive, including 4 tumors with no demonstrable m>CRTC1-MAML2m> fusion. In none of the cases was a m>CRTC3-MAML2m> fusion detected. No obvious correlation between the cellular composition and presence of t(11,19) translocation was found.
