Long-term alcohol exposure elicits hippocampal nonsynaptic epileptiform activity changes associated with expression and functional changes in NKCC1, KCC2 co-transporters and Na⁺/K⁺-ATPase

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• 作者：Luiz E.C. Santos^a ; Antô ; nio M. Rodrigues^a ; Mariana R. Lopes^a ; Victor D.C. Costa^a ; Carla A. Scorza^b ; Fulvio A. Scorza^b ; Esper A. Cavalheiro^b ; Antô ; nio-Carlos G. Almeida^a ; ^{acga@ufsj.edu.br}
• 关键词：ACSF ; artificial cerebrospinal fluid ; DG ; dentate gyrus ; LO ; latency of onset ; MDA ; maximum dentate activation ; NEA ; nonsynaptic epileptiform activities ; TBE ; time between events
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：340
• 期：Complete
• 页码：530-541
• 全文大小：3444 K
• 卷排序：340

文摘

Nonsynaptic effects of long-term alcohol exposure (3 months) on the hippocampus were investigated. Alcohol exposure changed NKCC1, KCC2 and Na-K-ATPase expressions. NEA enhanced due to alcohol exposure. Increase in DC shift is due to NKCC1 action. Neurodegeneration observed in the treated groups diminished with NKCC1 blockage.