Cardiac-specific overexpression of catalase prevents diabetes-induced pathological changes by inhibiting NF-κB signaling activation in the heart

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Cardiac-specific overexpression of catalase prevents diabetes-induced pathological changes by inhibiting NF-κB signaling activation in the heart

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作者：Weitao Cong^a ; ¹ ; Dandan Ruan^a ; ^b ; ¹ ; Yuanhu Xuan^a ; ¹ ; Chao Niu^a ; Youli Tao^a ; Yang Wang^c ; Kungao Zhan^d ; Lu Cai^e ; Litai Jin^a ; ^{jin_litai@126.com" class="auth_mail" title="E-mail the corresponding author} ; Yi Tan^a ; ^{ty1791561@163.com" class="auth_mail" title="E-mail the corresponding author}
关键词：CAT-TG ; cardiac-specific catalase overexpression transgenic ; WT ; wild type ; α-KGD ; α-oxoglutarate dehydrogenase E1 component ; KGDHC ; α-ketoglutarate dehydrogenase complex ; ATP-α ; ATP synthase α subunit ; ATP-β ; ATP synthase β subunit ; ROS ; reactive oxygen species ; RNS ; reactive nitrogen species ; LVEDD ; left ventricular end-diastolic dimension ; LVESD ; left ventricular end-systolic dimension ; LVIVS ; left ventricular interventricular septum wall thickness ; LVPWT ; left ventricular posterior wall thi
刊名：Journal of Molecular and Cellular Cardiology
出版年：2015
出版时间：December 2015
年：2015
卷：89
期：part_PB
页码：314-325
全文大小：2615 K

文摘

•: Overexpression of catalase prevents diabetes-induced pathological changes in the heart.
•: Catalase overexpression protects against diabetes-induced 3-nitrotyrosine (3-NT) modifications of key metabolic enzymes.
•: Catalase overexpression prevents diabetes-induced 3-NT modification by attenuating NF-κB-mediated inflammatory responses.

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