An update on the role of mitochondrial ¦Á-ketoglutarate dehydrogenase in oxidative stress

详细信息    查看全文

• 作者：Anatoly A. Starkov ^{ans2024@med.cornell.edu}
• 关键词：Mitochondria ; Oxidative stress ; Reactive oxygen species
• 刊名：Molecular and Cellular Neuroscience
• 出版年：2013
• 出版时间：July, 2013
• 年：2013
• 卷：55
• 期：Complete
• 页码：13-16
• 全文大小：187 K

文摘

The activity of mitochondrial alpha-ketoglutarate dehydrogenase complex (KGDHC) is severely reduced in human pathologies where oxidative stress is traditionally thought to play an important role, such as familial and sporadic forms of Alzheimer's disease and other age-related neurodegenerative diseases. This minireview is focused on substantial data that were accumulated over the last 2 decades to support the concept that KGDHC can be a primary mitochondrial target of oxidative stress and at the same time a key contributor to it by producing reactive oxygen species. This article is part of a Special Issue entitled ¡®Mitochondrial function and dysfunction in neurodegeneration¡¯.