A Pharmacokinetic and Pharmacodynamic Study of Maraviroc as Acute Graft-versus-Host Disease Prophylaxis in Pediatric Allogeneic Stem Cell Transplant Recipients with Nonmalignant Diagnoses
文摘

Maraviroc administration is feasible in pediatric allogeneic transplant recipients

Maraviroc at a dose of ~300 mg/m2 achieves acceptable plasma levels and functional blockade of chemokine receptor type 5

Maraviroc may be helpful in preventing acute visceral graft-versus-host disease in children with pre-existing enteropathy

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