The role of miR-190a in methylglyoxal-induced insulin resistance in endothelial cells

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• 作者：Paola Mirra^a ; ^b ; ¹ ; Cecilia Nigro^a ; ^b ; ¹ ; Immacolata Prevenzano^a ; ^b ; Teresa Procopio^a ; ^b ; Alessia Leone^a ; ^b ; Gregory Alexander Raciti^a ; ^b ; Francesco Andreozzi^c ; Michele Longo^a ; ^b ; Francesca Fiory^a ; ^b ; Francesco Beguinot^a ; ^b ; Claudia Miele^a ; ^b ; ^{c.miele@ieos.cnr.it}
• 关键词：AG ; aminoguanidine ; AGE ; advanced glycation end-product ; Akt ; protein kinase B ; eNOS ; endothelial NO synthase ; ERK ; extracellular signal-regulated protein kinase ; Glo1 ; glyoxalase 1 ; HDAC ; histone deacetylase ; HUVECs ; human umbilical vein endothelial cells ; IRS-1 ; insulin receptor substrate 1 ; KRAS ; kirsten rat sarcoma viral oncogene homolog ; MAECs ; mouse aortic endothelial cells ; MAPK ; mitogen-activated protein kinase ; MEK ; MAPK ERK kinase ; MGO ; methylglyoxal ; miRNAs ; microRNAs ; NO ; nitric oxid
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1863
• 期：2
• 页码：440-449
• 全文大小：852 K
• 卷排序：1863

文摘

MGO exposure reduces the expression of miRNA-190a in MAECs. miR-190a affects insulin sensitivity in MAECs. miR-190a down-regulation contributes to MGO-induced endothelial insulin-resistance by increasing KRAS protein levels.