Regulation of proteasome activity by P2Y₂ receptor underlies the neuroprotective effects of extracellular nucleotides

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• 作者：Laura de Diego-Garcí ; a^a ; ^c ; Mercedes Ramí ; rez-Escudero^a ; Á ; lvaro Sebastiá ; n-Serrano^a ; ^c ; Juan Ignacio Diaz-Herná ; ndez^a ; ^d ; Jesú ; s Pintor^b ; José ; J. Lucas^d ; ^e ; Miguel Dí ; az-Herná ; ndez^a ; ^c ; ^{migueldiaz@ucm.es}
• 关键词：UPS ; Ubiquitin-Proteasome System ; P2Y2R ; P2Y2 receptor ; IP3 ; inositol 1 ; 4 ; 5-trisphosphate ; MEK1/2 ; MAP kinase kinases ; ERK ; extracellular signal-regulated kinase ; PKC ; protein kinase C ; PKA ; protein kinase A ; PI3K ; inositol 1 ; 4 ; 5-trisphosphate 3-kinases ; MAPK/ERK ; mitogen-activated protein kinases ; GFP ; green fluorescent protein ; YFP ; yellow fluorescent protein ; ATP ; adenosine triphosphate ; UTP ; uridine triphosphate ; PPADS ; pyridoxalphosphate-6-azophenyl-2&prime ; 4&prime ; -disulfonic acid ; Up4U
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1863
• 期：1
• 页码：43-51
• 全文大小：1102 K
• 卷排序：1863

文摘

The P2Y2R enhances UPS activity by increasing the subunits expression β5 and β1. The intracellular signaling pathway involved requires activation of IP3/MEK1/2/ERK. The neuroprotective role of nucleotides may lie in its ability to modulate the UPS.