The purpose of this study w
as to ex
amine the tempor
al trends in demogr
aphics, clinic
al ch
ar
acteristics, m
an
agement str
ategies,
and in-hospit
al outcomes in p
atients with
acute myoc
ardi
al inf
arction complic
ated by c
ardiogenic shock (CS-AMI) who underwent percut
aneous coron
ary intervention (PCI) from the C
ath-PCI Registry (2005 to 2013).
absSec_2">Background
abspara0015">The authors examined contemporary use and outcomes of PCI in patients with CS-AMI.
absSec_3">Methods
abspara0020">The authors used the Cath-PCI Registry to evaluate 56,497 patients (January 2005 to December 2013) undergoing PCI for CS-AMI. Temporal trends in clinical variables and outcomes were assessed.
absSec_4">Results
abspara0025">Compared with cases performed from 2005 to 2006, CS-AMI patients receiving PCI from 2011 to 2013 were more likely to have diabetes, hypertension, dyslipidemia, previous PCI, dialysis, but less likely to have chronic lung disease, peripheral vascular disease, or heart failure within 2 weeks (p < 0.01). Between 2005 and 2006 to 2011 and 2013, intra-aortic balloon pump use decreased (49.5% to 44.9%; p < 0.01), drug-eluting stent use declined (65% to 46%; p < 0.01), and the use of bivalirudin increased (12.6% to 45.6%). Adjusted in-hospital mortality; increased (27.6% in 2005 to 2006 vs. 30.6% in 2011 to 2013, adjusted odds ratio: 1.09, 95% confidence interval: 1.005 to .173; p = 0.04) for patients who were managed with an early invasive strategy (<24 h from symptoms).
absSec_5">Conclusions
abspara0030">Our study shows that despite the evolution of medical technology and use of contemporary therapeutic measures, in-hospital mortality in CS-AMI patients who are managed invasively continues to rise. Additional research and targeted efforts are indicated to improve outcomes in this high-risk cohort.