Human oligodendrocytes express Cx31.3: Function and interactions with Cx32 mutants

详细信息    查看全文

• 作者：Irene Sargiannidou ; Meejin Ahn ; Alan D. Enriquez ; Alej ; ro Peinado ; Richard Reynolds ; Charles Abrams ; Steven S. Scherer ; Kleopas A. Kleopa
• 关键词：CMT1X ; Connexin29 ; Gap junctions ; Protein trafficking ; Hemichannels
• 刊名：Neurobiology of Disease
• 出版年：2008
• 出版时间：May 2008
• 年：2008
• 卷：30
• 期：2
• 页码：221-233
• 全文大小：2246 K

文摘

Murine oligodendrocytes express the gap junction (GJ) proteins connexin32 (Cx32), Cx47, and Cx29. CNS phenotypes in patients with X-linked Charcot–Marie–Tooth disease may be caused by dominant effects of Cx32 mutations on other connexins. Here we examined the expression of Cx31.3 (the human ortholog of murine Cx29) in human brain and its relation to the other oligodendrocyte GJ proteins Cx32 and Cx47. Furthermore, we investigated in vitro whether Cx32 mutants with CNS manifestations affect the expression and function of Cx31.3.