Identification of a Post-translational Modification with Ribitol-Phosphate and Its Defect in Muscular Dystrophy

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Identification of a Post-translational Modification with Ribitol-Phosphate and Its Defect in Muscular Dystrophy

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作者：Motoi Kanagawa¹ ; ⁷ ; Kazuhiro Kobayashi¹ ; ⁷ ; Michiko Tajiri² ; ⁷ ; Hiroshi Manya³ ; ⁷ ; Atsushi Kuga¹ ; ⁷ ; Yoshiki Yamaguchi⁴ ; Keiko Akasaka-Manya³ ; Jun-ichi Furukawa⁵ ; Mamoru Mizuno⁶ ; Hiroko Kawakami⁶ ; Yasuro Shinohara⁵ ; Yoshinao Wada² ; ⁸ ; ^{waday@lab.mch.pref.osaka.jp" class="auth_mail" title="E-mail the corresponding author} ; Tamao Endo³ ; ⁸ ; ^{endo@tmig.or.jp" class="auth_mail" title="E-mail the corresponding author} ; Tatsushi Toda¹ ; ⁸ ; ^{toda@med.kobe-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2016
出版时间：8 March 2016
年：2016
卷：14
期：9
页码：2209-2223
全文大小：4761 K

文摘

•: Ribitol 5-phosphate is a functional glycan unit in mammals
•: α-dystroglycan function requires tandem ribitol 5-phosphate structure
•: Muscular dystrophy proteins are involved in ribitol 5-phosphate glycosylation
•: Supplementation with ribitol 5-phosphate metabolites may be a therapeutic strategy

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