Lack of association of rs3798220 with small apolipoprotein(a) isoforms and high lipoprotein(a) levels in East and Southeast Asians

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Lack of association of rs3798220 with small apolipoprotein(a) isoforms and high lipoprotein(a) levels in East and Southeast Asians

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作者：Mahmoud Khalifa^a ; ^b ; ¹ ; ² ; Asma Noureen^a ; ^b ; ¹ ; Kathrin Ertelthalner^a ; Ahmad Reza Bandegi^b ; ³ ; Rhena Delport^b ; ^c ; Wance J.J. Firdaus^b ; ⁴ ; Finney S. Geethanjali^b ; ^d ; Kalpana Luthra^b ; ^e ; Orawan Makemaharn^b ; ^f ; Richard W.C. Pang^b ; ^g ; Abdel-Halim Salem^b ; ⁵ ; Jun Sasaki^h ; Wulf Schiefenhoevelⁱ ; Arno Lingenhel^a ; ^b ; Florian Kronenberg^a ; Gerd Utermann^b ; Konrad Schmidt^a ; ^b ; ^j ; ^k ; ^{konrad.schmidt@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author} ; ^{konrad.schmidt@afrigene.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Copy number variation ; Coronary artery disease ; Genetic variation ; Lipoprotein(a) ; Population genetics
刊名：Atherosclerosis
出版年：2015
出版时间：October 2015
年：2015
卷：242
期：2
页码：521-528
全文大小：544 K

文摘

•: rs3798220 is associated with long rather than short KIV-2 CNV alleles in Asians.
•: rs3798220 variant alleles are not associated with high Lp(a) in these populations.
•: This likely explains why this SNP in LPA is not associated with CAD in Asians.

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