Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions

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Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions

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作者：Rajat Kumar¹ ; ^{rkumar@cancercare.mb.ca" class="auth_mail" title="E-mail the corresponding author} ; Fumihiko Kimura² ; Kwang Woo Ahn³ ; Zhen-Huan Hu³ ; Yachiyo Kuwatsuka³ ; ⁴ ; John P. Klein³ ; Marcelo Pasquini³ ; Koichi Miyamura⁵ ; Koji Kato⁶ ; Ayami Yoshimi⁷ ; Yoshihiro Inamoto⁸ ; Tatsuo Ichinohe⁹ ; William Allen Wood Jr.¹⁰ ; Baldeep Wirk¹¹ ; Matthew Seftel¹ ; Philip Rowlings¹² ; David I. Marks¹³ ; Kirk R. Schultz¹⁴ ; Vikas Gupta¹⁵ ; Laurence Dedeken¹⁶ ; Biju George¹⁷ ; Jean-Yves Cahn¹⁸ ; Jeff Szer¹⁹ ; Jong Wook Lee²⁰ ; Aloysius Y.L. Ho²¹ ; Anders Fasth²² ; Theresa Hahn²³ ; Nandita Khera²⁴ ; Jignesh Dalal²⁵ ; Carmem Bonfim²⁶ ; Mahmoud Aljurf²⁷ ; Yoshiko Atsuta²⁸ ; Wael Saber³
关键词：Aplastic anemia ; Hematopoietic cell transplantation ; Graft source ; Economic regions
刊名：Biology of Blood and Marrow Transplantation
出版年：2016
出版时间：May 2016
年：2016
卷：22
期：5
页码：932-940
全文大小：1039 K

文摘

•: Overall survival was better with bone marrow as graft source in sibling transplants for aplastic anemia.
•: Chronic graft-versus-host disease was worse with peripheral blood stem cells as graft source.
•: In non–high-income countries, there was no significant survival difference between the 2 graft sources.
•: Analysis of registry data should cater to variations in outcomes in different economic regions.