Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host

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• 作者：Ada W.C. Yan^a ; Pengxing Cao^a ; Jane M. Heffernan^b ; ^c ; Jodie McVernon^d ; ^e ; ^f ; Kylie M. Quinn^g ; ^h ; Nicole L. La Gruta^g ; ^h ; Karen L. Laurieⁱ ; ^j ; ^g ; James M. McCaw^a ; ^e ; ^f ; ^{jamesm@unimelb.edu.au}
• 关键词：Mathematical model ; Viral dynamics ; Immunology ; Cytotoxic T lymphocyte
• 刊名：Journal of Theoretical Biology
• 出版年：2017
• 出版时间：21 January 2017
• 年：2017
• 卷：413
• 期：Complete
• 页码：34-49
• 全文大小：1508 K
• 卷排序：413

文摘

We model a T cell response to influenza which is cross-reactive between strains. Cross-reactivity in the T cell immune response changes successive infection outcomes. The interval between pathogen exposures varies the effect of the T cell response. We model three biological factors affecting the strength of the T cell response.