Four structural subclasses of the antivirulence drug target disulfide oxidoreductase DsbA provide a platform for design of subclass-specific inhibitors

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Four structural subclasses of the antivirulence drug target disulfide oxidoreductase DsbA provide a platform for design of subclass-specific inhibitors

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作者：Ró ; isí ; n M. McMahon¹ ; ^{r.mcmahon@imb.uq.edu.au" class="auth_mail} ; Lakshmanane Premkumar¹ ; ^{p.lakshmanane@uq.edu.au" class="auth_mail} ; Jennifer L. Martin ; ^{j.martin@imb.uq.edu.au" class="auth_mail}
关键词：Antivirulence ; Disulfide bond formation ; DsbA ; Antibiotic resistance ; Structural classification
刊名：Biochimica et Biophysica Acta - Proteins and Proteomics
出版年：August 2014
年：2014
卷：1844
期：8
页码：1391-1401
全文大小：2336 K

文摘

•: The bacterial DsbA enzyme is a master regulator of virulence.
•: DsbA crystal structures from 13 organisms were compared.
•: DsbA structures were categorized into two major classes and four subclasses.
•: DsbA subclasses provide a platform for developing specific DsbA inhibitors.

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