Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans

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Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans

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作者：Petra Bacher¹ ; Frederik Heinrich² ; Ulrik Stervbo³ ; ⁵ ; Mikalai Nienen³ ; Marco Vahldieck⁴ ; Christina Iwert⁵ ; Katrin Vogt⁵ ; Jutta Kollet⁴ ; Nina Babel³ ; ⁵ ; Birgit Sawitzki⁵ ; Carsten Schwarz⁶ ; Stefan Bereswill⁷ ; Markus M. Heimesaat⁷ ; Guido Heine⁸ ; Gabriele Gadermaier⁹ ; Claudia Asam⁹ ; Mario Assenmacher⁴ ; Olaf Kniemeyer¹⁰ ; Axel A. Brakhage¹⁰ ; Fá ; tima Ferreira⁹ ; Michael Wallner⁹ ; Margitta Worm⁸ ; Alexander Scheffold¹ ; ² ; ¹¹ ; ^{alexander.scheffold@charite.de" class="auth_mail" title="E-mail the corresponding author}
关键词：allergy ; regulatory T cell ; treg ; antigen-specific T cell ; birch pollen ; aspergillus fumigatus ; CD154 (CD40L) ; CD137 (4-1BB) ; tolerance ; allergen
刊名：Cell
出版年：2016
出版时间：3 November 2016
年：2016
卷：167
期：4
页码：1067-1078.e16
全文大小：7019 K

文摘

•: A comprehensive characterization of antigen-specific human Treg responses
•: Harmless aeroantigens are major tolerogenic Treg targets
•: Allergic patients have intact Treg responses against aeroantigens
•: Th2 responses escape Treg control due to divergent antigen specificities

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