Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

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• 作者：Han Gaop>1p>p> ; p>p>2p> ; Matt C. Danzip>1p>p> ; p>p>2p>p> ; p>p>3p> ; Claire S. Choip>4p> ; Mehran Taherianp>1p> ; Camilla Dalby-Hansenp>1p>p> ; p>p>5p> ; Ditte G. Ellmanp>5p> ; Pernille M. Madsenp>1p>p> ; p>p>5p> ; John L. Bixbyp>1p>p> ; p>p>2p>p> ; p>p>3p>p> ; p>p>6p> ; Vance P. Lemmonp>1p>p> ; p>p>2p>p> ; p>p>3p> ; Kate L. Lambertsenp>5p>p> ; p>p>7p>p> ; p>p>8p> ; Roberta Brambillap>1p>p> ; p>p>2p>p> ; p>p>9p>p> ; p>p>r.brambilla@miami.edup>
• 关键词：multiple sclerosis ; cytokines ; neuroinflammation ; tumor necrosis factor ; TNF signaling ; microglia ; macrophages
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：18
• 期：1
• 页码：198-212
• 全文大小：6303 K
• 卷排序：18

文摘

TNFR2 has opposing functions in microglia and monocytes/macrophages in EAE Microglial TNFR2 mediates protective responses at EAE onset Monocyte/macrophagic TNFR2 is detrimental in EAE by driving autoimmune activation