C3 transferase gene therapy for continuous conditional RhoA inhibition

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C3 transferase gene therapy for continuous conditional RhoA inhibition

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作者：Claire-Anne Gutekunst^a ; ^{cguteku@emory.edu" class="auth_mail" title="E-mail the corresponding author} ; Jack K. Tung^a ; ^c ; ^{jtung@emory.edu" class="auth_mail" title="E-mail the corresponding author} ; Margaret E. McDougal^a ; ^{mmcdoug@emory.edu" class="auth_mail" title="E-mail the corresponding author} ; Robert E. Gross^a ; ^b ; ^c ; ^{rgross@emory.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：AAV2 ; adeno-associated serotype 2 virus ; CNS ; central nervous system ; C3 ; C3 transferase ; CBA ; chicken β-actin ; CSPGs ; chondroitin sulfate proteoglycans ; DMEM ; Dulbecco&rsquo ; s Modified Eagle&rsquo ; s medium ; eC3 ; endogenous C3 ; EGFP ; enhanced GFP ; HEK ; Human embryonic kidney ; hUbC ; Ubiquitin C ; ICC ; immunocytochemistry ; KRAB ; Kruppel-associated box ; LV ; lentiviral vectors ; NGS ; normal goat serum ; NDS ; normal donkey serum ; ONC ; optic nerve crush ; PLL ; poly-l-lysine ; PCR ; polymerase chain reaction
刊名：Neuroscience
出版年：2016
出版时间：17 December 2016
年：2016
卷：339
期：Complete
页码：308-318
全文大小：1332 K

文摘

•: Viral vectors expressing endogenous or secretable/permeable forms of C3 transferase were generated.
•: Endogenous and secretable/permeable C3 transferase promotes cell process growth on inhibitory substrates.
•: A conditional secretable/permeable C3 shows reuptake by adjacent cells for more widespread effects.

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