Smad4 is required for the development of cardiac and skeletal muscle in zebrafish

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Smad4 is required for the development of cardiac and skeletal muscle in zebrafish

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作者：Jie Yang¹ ; ^{yangjie@tjh.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Junnai Wang¹ ; ^{865646064@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Zhen Zeng ^{304527694@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Long Qiao ^{498801939@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Liang Zhuang ^{mrzhuangliang@126.com" class="auth_mail" title="E-mail the corresponding author} ; Lijun Jiang ^{278308418@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Juncheng Wei ^{191320607@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Quanfu Ma ^{99213704@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Mingfu Wu ^{wumingfuwh@aliyun.com" class="auth_mail" title="E-mail the corresponding author} ; Shuangmei Ye ^{29011378@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Qinglei Gao ^{2482880446@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Ding Ma ^{dma@tjh.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Xiaoyuan Huang ; ^{huangxy@tjh.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：smad4 ; SMAD family member 4 ; vmhc ; ventricular myosin heavy chain ; amhc ; myh6 myosin ; heavy chain 6 ; cardiac muscle ; alpha ; cmlc2 ; myl7 ; myosin ; light chain 7 ; regulatory
刊名：Differentiation
出版年：2016
出版时间：October-November 2016
年：2016
卷：92
期：4
页码：161-168
全文大小：2111 K

文摘

•: Smad4 was expressed at all developmental stages of zebrafish.
•: Knockdown of smad4 in embryos resulted in defects in the heart and the trunk structure.
•: Knockdown of smad4 in embryos downregulated the expression of two heart-chamber markers.
•: Knockdown of smad4 in embryos increased the expression of myogenic regulatory factors.
•: Knockdown of smad4 in embryos resulted in an obvious increase of cell apoptosis.