SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV

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SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV

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作者：George E. Greco^a ; Yoshihiro Matsumoto^b ; Rhys C. Brooks^b ; Zhengfei Lu^c ; Michael R. Lieber^c ; Alan E. Tomkinson^b ; ^{atomkinson@salud.unm.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Human DNA ligases ; DNA ligase inhibitors ; DNA double strand break repair ; Non-homologous end-joining
刊名：DNA Repair
出版年：2016
出版时间：July 2016
年：2016
卷：43
期：Complete
页码：18-23
全文大小：1188 K

文摘

•: Synthesis and structure of the putative DNA ligase IV inhibitor, SCR7, and related derivatives.
•: SCR7 derivatives weakly inhibit DNA ligase IV in vitro.
•: SCR7 derivatives are more active against DNA ligases I and III than DNA ligase IV.
•: SCR7 does not inhibit DNA ligase IV-dependent V(D)J recombination in a cell-based assay.

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