The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2

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• 作者：Paolo Swuec¹ ; Ludovic Renault¹ ; ⁴ ; Aaron Borg² ; Fenil Shah³ ; ⁵ ; Vincent J. Murphy³ ; Sylvie van Twest³ ; Ambrosius P. Snijders² ; Andrew J. Deans³ ; Alessandro Costa¹ ; ⁶ ; ^{alessandro.costa@crick.ac.uk}
• 关键词：interstrand crosslink ; Fanconi anemia ; ubiquitin ligase ; DNA repair ; cryo-electron microscopy ; mono-ubiquitination
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：18
• 期：3
• 页码：611-623
• 全文大小：4579 K
• 卷排序：18

文摘

FANCB, FANCL, and FAAP100 form a symmetric dimer of trimers FANCL is ideally poised for the symmetric mono-ubiquitination of FANCI-FANCD2 Two separate FANCC-FANCE-FANCF complexes bind to the opposing poles of FANCB-FANCL-FAAP100 FANCC-FANCE-FANCF stabilizes FANCI-FANCD2 for efficient mono-ubiquitination