Novel PDE10A transcript diversity in the human striatum: Insights into gene complexity, conservation and regulation

详细信息    查看全文

• 作者：Courtney M MacMullen^a ; Mohammad Fallahi^b ; Ronald L Davis^a ; ^{rdavis@scripps.edu}
• 关键词：SNP ; single nucleotide polymorphism ; cAMP ; cyclic adenosine monophosphate ; cGMP ; cyclic guanosine monophosphate ; MSN ; medium spiny neurons ; HC ; healthy control ; BD ; bipolar disorder ; RLM-RACE ; RNA ligase mediated rapid amplification of cDNA ends ; IRB ; institutional review board ; RNA ; ribonucleic acid ; NCBI ; National Center for Biotechnology ; RT-PCR ; reverse transcriptase polymerase chain reaction ; UCSC ; University of California Santa Cruz ; DNA ; deoxyribonucleic acid ; TFIIB ; transcription factor
• 刊名：Gene
• 出版年：2017
• 出版时间：30 March 2017
• 年：2017
• 卷：606
• 期：Complete
• 页码：17-24
• 全文大小：645 K
• 卷排序：606

文摘

15 different PDE10A transcripts are now cataloged in the human brain The novel PDE10A transcripts have unique 5′ sequences but retain identical sequences in the carboxyl-half of the protein Novel PDE10A exons are conserved in non-human primate species and are rarely found in other mammals 108 “intronic” SNPs, of which 78% are rare variants, were found in the novel PDE10A exons, most residing in the 5’UTRs